MicroRNA: Another Pharmacological Avenue for Colorectal Cancer?

Pharmacological Prevention of Colorectal Cancer COLORECTAL CANCER

Colorectal cancer (CRC) is a prevalent cause of morbidity and mortality in the western world. CRC carcinogenesis is a multi-step process that spans over many years providing an opportunity for intervention and cancer prevention. Science and technology have evolved to a point where we are able to use our knowledge of cancer biology to identify individuals at risk and interrupt the process of mal...

Pharmacological and dietary prevention for colorectal cancer

BACKGROUND Colorectal cancer (CRC) is a leading cause of cancer morbidity and mortality. People at higher risk are those individuals with a family history of CRC and familial adenomatous polyposis. Prevention and screening are two milestones for this disease. The aim of this study is to evaluate the chemopreventive role of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin and cy...

MicroRNA signatures: novel biomarker for colorectal cancer?

Aberrant microRNA (miRNA) expression might be of potential use as diagnostic and prognostic biomarker for cancers. We reviewed studies published until March 2011 which assessed expression of miRNAs in colorectal cancer (CRC)/adenoma tissue and normal colorectal mucosa and in plasma of CRC/adenoma patients and healthy controls. Overall, 20 studies that investigated miRNA expression in tissue and...

Can Dietary and Pharmacological Supplements Prevent Colorectal Cancer ? COLORECTAL CANCER

14 For some time, there has been an effort made to identify and evaluate dietary components and chemical compounds (chemopreventive agents) that could prevent, inhibit or change the course of colorectal (CR) carcinogenesis (1). These efforts were based on clinical and lay observations, beliefs and epidemiological correlations, that certain foods or additives had beneficial anti-carcinogenic pro...

MicroRNA expression in colorectal cancer.